The following is a sample of some clinical trials related to myopia that are listed in the database at http://clinicaltrials.gov. Not all trials will publish their results. A larger database from the World Health Organization (WHO) can be found at http://apps.who.int/trialsearch/default.aspx. The WHO database is a compilation from 12 different registries around the world.
Toric Orthokeratology - Slowing Eye Elongation (TO-SEE) Sponsor: The Hong Kong Polytechnic University. Pricipal Investigator: Pauline Cho. "The current study aims at investigating the efficacy of toric ortho-k lenses for correcting myopic astigmatism and for retarding myopic progression in children compared to children wearing single-vision spectacles." Estimated completion date: December 2011
Myopic Control for High Myopes Using Orthokeratology (HM-PRO) Sponsor: The Hong Kong Polytechnic University. Principal Investigator: Pauline Cho.Myopes greater than 5.75D sphere will wear ortho-k lenses at night and spectacles for residual refractive error during the day to see if ortho-k is effective for myopia control in this population. Estimated completion date: April 2012
Study of Theories About Myopia Progression (STAMP) Sponsor: Ohio State University. Principal Investigators: David A Berntsen, OD, MS, Karla Zadnik, OD, PhD, Donald O Mutti, OD, PhD. Students with a lag of accommodation >= 1.30 D (for a 4D stimulus) and a near esophoria if more than -2.25D myopic will wear progressive addition lenses (PALs) with a +2.00 add for one year and then single vision lenses for one year. The control group will wear single vision lenses for two years. Estimated completion: June 2010
Myopia Control With Simultaneous Vision Approach Sponsor: The Hong Kong Polytechnic University. Principal Investigator: Carly SY Lam, PhD. Students will wear simultaneous vision bifocal soft contact lenses for 2.5 years. The control group will wear single vision soft contact lenses. Estimated completion: June 2010
Bifocal Soft Contact Lenses and Their Effect on Myopia Progression in Children and Adolescents Sponsor: Thomas Aller, O.D. with Vistakon as a collaborator. Principal Investigator: Thomas A. Aller, O.D. Students will wear bifocal contact lenses of varying add powers. The control group will wear single vision soft contact lenses. Completed 2006. No published results.
Correction of Myopia Evaluation Trial (COMET) Sponsor: National Eye Institute. Study chair: Jane Gwiazda, PhD, New England College of Optometry. Students will wear Progressive Addition Lenses (PALs). The control group received single vision lenses. Begun in 1996, COMET was the first-ever clinical trial in optometry, according to Dr. Gwiazda's web site. Ongoing analysis of subgroups.
The Contact Lens and Myopia Progression (CLAMP) Study Sponsor: National Eye Institute. Study located at The Ohio State University College of Optometry. The results were published in Arch Ophthalmol. 2004 Dec;122(12):1760-6 with the title "A randomized trial of the effects of rigid contact lenses on myopia progression."
Correction of Myopia Evaluation Trial 2 (COMET2) Sponsor: Jaeb Center for Health Research. Study Chair: Jane Gwiazda, Ph.D. Students with near esophoria wear progressive addition lenses (PALs) with a +2.00 add while the control group wears single vision lenses. Duration = 3 yrs. A second nested study is to determine if Monocular Estimate Method (MEM) or Nott retinoscopy can be used to identify accommodative lag in a clinician's typical office.
Evaluating NeuroVision's Neural Vision Correction (NVC) Myopia Treatment Sponsor: Ohio State University. Principal Investigator: Donald O Mutti, O.D. A trial of the NVC system of visual stimulations on a computer screen designed to act on specific neuronal interactions in visual cortex to enhance neural processing and thus compensate for myopic inputs. NeuroVision has a public website where it claims one may be able to see 20/20 without losing their myopia. (FAQ page) Completed December 2008.
Assessment of Bifocal and Prismatic Bifocal Spectacles for Myopia Control in Children Sponsor: Essilor International. Principal Investigator: Desmond Cheng, OD, MSc Queensland University of Technology. Study of bifocals to determine if different variables such as age, gender, higher myopic progression, near phoria and lag of accommodation affects the efficacy of wear. Completed April 2008
Does Undercorrection of Myopia Retard Myopia Progression Among Kindergarten Children? Sponsor: KK Women's and Children's Hospital. Principal Investigator: Quah Boon Long, Singapore National Eye Centre. To see if undercorrection of myopia slows progression in children age 5-6. Completed November 2006?
Myopia Progression and the Effect of 7-Methylxanthine Sponsor: Trier Research Laboratories. Study Chair: Klaus Trier, MD. Trier Research Laboratories. Tablets of 7-methylxanthine 400 mg per day are studied for control of myopic progression as well as systemic findings such as weight, height, blood pressure and heart rate. 90 students ages 8-13.
Pilot Study to Assess the Efficacy of Short Exposure to Defocus to Slow the Progression of Myopia in Children Sponsor: Singapore National Eye Centre. Principal Investigator: Audrey Chia, FRANZCO, Singapore National Eye Center. Since the STOP signal for axial growth has been shown in some animals to be very strong with only brief periods of high myopic defocus able to overcome prolonged periods of hyperopic defocus, this study will attempt to see if brief periods of high plus lenses will slow myopic progression. This is different than undercorrection which results in only mild myopic defocus. Study completion: October 2008.
Trial of Myopia Prevention Using +3D Lenses (PLS) Sponsor: Sun Yat-sen University. Study Director: Mingguang He, PhD, MD. Zhongshan Ophthalmic Center. This study to determine if wearing +3.00 lenses for 30 minutes a day while engaged in activities requiring vision over 1 meter away will prevent myopic progression. Estimated completion date: April 2012
Pilot Study of Neurovision to Improve Vision and Slow Myopia Progression in Children With Myopia Sponsor: Singapore National Eye Centre. Principal Investigators: Donald Tan, FRCS, Singapore Eye Research Institute; Wei Han Chua, FRCS, Singapore National Eye Centre. A study of NeuroVision's technology to improve visual acuity. Completion date: April 2009
Cambridge Anti-Myopia Trial: Accommodation Training and Aberration Control in Myopia Development "investigating the role of contact lenses along with vision training in the regulation of myopic progression. Multifocal contact lenses worn in conjunction with vision training for modulating the AC/A ratio may hold promise." says Jerome Legerton. See Aberration Control and Vision Training as an Effective Means of Improving Accommodation in Individuals with Myopia
Retardation of Myopia in Orthokeratology (ROMIO) Sponsor: The Hong Kong Polytechnic University. Principal Investigator: Pauline Cho, PhD, The Hong Kong Polytechnic University. Although orthokeratology has been shown to have the potential for slowing myopic progression, this is a randomized clinical trial to determine if axial length growth is slowed compared to a control group wearing single vision spectacles. Estimated completion date: December 2011
Study of Myopia Acquisition and Prevention (SMART) Sponsor: University Hospital Freiburg. Study Chair: Alexaner Reis, PD Dr. med. Augenwerk, Liechtenstein. Another study with the acronym "SMART". This was a study of 115 children ages 7-9 wearing +2.00 reading glasses to see if it slows myopic progression. Completion date: October 2008
Peripheral Optics in Myopia and Orthokeratology Sponsor: The Hong Kong Polytechnic University. Principal Investigator: Pauline Cho, PhD., School of Optometry, The Hong Kong Polytechnic University. A study of peripheral refractions in children wearing orthokeratology lenses vs single vision spectacles. Estimated completion date: June 2012
Eye Acceleration of Growth of Refractive Attributes (EYEAGRA) Sponsor: Aller, Thomas A., OD. Principal Investigator: Thomas A Aller, O.D. Unaffiliated. Bifocal contact lenses will be studied to see if they can correct hyperopia. "The bifocal contact lenses will be prescribed to provide for clear central vision at both distance and near with the near zone of the contact, thus exposing the retina to hyperopic defocus from the distance zone." MyopiaPrevention comment: This falls under hyperopia prevention, a less common condition but also debilitating.
Guangzhou Outdoor Activity Longitudinal Study Sponsor: Sun Yat-sen University. Principal Investigators: Mingguang He, PhD, MD, Zhongshan Ophthalmic Center; Ian Morgan, PhD, Australian National University. This study of 1500 Chinese school children is to determine if increased engagement in outdoor activities will slow myopic progression. Estimated completion date: July 2012